Jancke D, Herlitze S, Kringelbach ML, Deco G (2022).

Bridging the gap between single receptor type activity and whole‐brain dynamics

The FEBS Journal, State-of-the-art Review, 289, 2067-2084 (Open Access) doi: https://doi.org/10.1111/febs.15855

How single neuronal receptor types influence entire brain dynamics remains elusive. We propose a model that combines the brain’s anatomical and functional constraints with Michaelis-Menten kinetics at individual receptor sites, exemplified by the serotonergic (5-HT) system. Further we show how optogenetic tools can be used for evaluation of our hypotheses in animal experiments. Our approaches may trigger new ways for the diagnosis and treatment of psychiatric disorders associated with malfunction of neurotransmitter systems.

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