How serotonin balances internal brain activity and external visual input
Azimi Z, Barzan R, Spoida K, Surdin T, Wollenweber P, Mark MD, Herlitze S, Jancke D (2020).
Separable gain control of ongoing and evoked activity in the visual cortex by serotonergic input
eLife 9: e53552 (Open Access) doi: 10.7554/eLife.53552
By combining state-of-the-art optogenetics, wide-field optical imaging, electrophysiology and pharmacological manipulations in vivo, we show that serotonergic neurons modulate both spontaneous and visually evoked responses by two separable cellular mechanisms. This study highlights an important, yet less examined role of serotonin in sensory processing.
Press release, Pressemitteilung (english, deutsch)