How serotonin balances internal brain activity and external visual input

Azimi Z, Barzan R, Spoida K, Surdin T, Wollenweber P, Mark MD, Herlitze S, Jancke D (2020).

Separable gain control of ongoing and evoked activity in the visual cortex by serotonergic input

eLife 9: e53552 (Open Access) doi: 10.7554/eLife.53552

By combining state-of-the-art optogenetics, wide-field optical imaging, electrophysiology and pharmacological manipulations in vivo, we show that serotonergic neurons modulate both spontaneous and visually evoked responses by two separable cellular mechanisms. This study highlights an important, yet less examined role of serotonin in sensory processing.

Press release, Pressemitteilung (english, deutsch)

Published online in eLife

PD Dr. Dirk Jancke

Institut für Neuroinformatik NB2/27
Ruhr University Bochum
44780 Bochum
Germany

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E-Mail: dirk.jancke@rub.de