How a single receptor-type modulates sensory gain across cortical circuits
Barzan R, Bozkurt B, Nejad MM, Süß S, Surdin T, Böke H, Spoida K, Azimi Z, Grömmke M, Eickelbeck D, Mark MD, Rohr L, Siveke I, Cheng S, Herlitze S, Jancke D (2024).
Gain control of sensory input across polysynaptic circuitries in mouse visual cortex by a single G protein-coupled receptor type (5-HT2A).
Nat Commun 15, 8078 (Open Access)
Neuromodulators influence the brain's global state and therefore all processing streams. In this study we show how a specific serotonin receptor (5-HT2A) controls gain of visual input without affecting ongoing brain broadcasts.
Press release, Pressemitteilung (english, deutsch)